PUBLICATIONS
Publications
Cigana, B.; Lapointe, V.; Majewski, M. B.; Forgione, P. A Modular and Catalytic Methodology To Access 2,5-Furan-Based Phenylene/Thiophene Oligomers through a One-Pot Decarboxylative Cross-Coupling from 5-bromofurfural, J. Org. Chem. 2024. DOI
Charoughchi, S.; Liu, J. T.; Berteau-Rainville, M.; Hase, H.; Askari, M. S.; Bhagat, S.; Forgione, P.; Salzmann, I. Sterically-Hindered Molecular p-Dopants Promote Integer Charge Transfer in Organic Semiconductors, Angew. Chem. Int. Ed. 2023, 62, e202304964. DOI
Hernandez, R. A.; Trakakis, I.; Do, J-L.; Cuccia, L. A.; Friščić, T.; Forgione, P. Mechanochemical Desymmetrization of Unbiased Bis- and Tris-alkynes to Access 3,5-Isoxazoles-Alkyne Adducts and Unsymmetrical Bis-3,5-isoxazoles, Eur. J. Org. 2023, 26, e202300374. DOI
Bertin, C.; Cruché, C.; Chacón-Huete, F.; Forgione, P.; Collins, S. K. Decomposition of lignin models enabled by copper-based photocatalysis under biphasic conditions, Green. Chem. 2022, 24, 4414. DOI
Chacón-Huete, F.; Messina, C.; Cigana, B.; Forgione, P. Diverse Applications of Biomass-Derived 5-Hydroxymethylfurfural and Derivatives as Renewable Starting Materials, ChemSusChem, 2022, e202200328. DOI
Buonomano, C.; Holtz-Mulholland, M.; Sullivan, S.; Forgione, P. Development of a Palladium-Catalyzed Decarboxylative Arene Cross-Coupling of Pyrrole Derivatives in a Flow Reactor, Journal of Flow Chemistry, 2022. DOI
Hernandez, R.A.; Burchell-Reyes, K.; Braga, A.; Keough Lopez, K.; Forgione, P. Solvent-Free Synthesis of 3,5-Isoxazoles Via 1,3-Dipolar Cycloaddition of Terminal Alkynes and Hydroxyimidoyl Chlorides over Cu/Al2O3 Surface under Ball-Milling Conditions, RSC Advances, 2022, 12, 6396-6402. DOI
Chacón-Huete, F.; Covone, J.; Zaroubi, L.; Forgione, P. Efficient Synthesis of Bis(5-arylfuran-2-yl)methane Scaffolds Utilizing Biomass-Derived Starting Materials, Eur. J. Org. Chem, 2022, e202101571. DOI
Jaunky, D.B.; Laroque, K.; Liu, J.T.; Forgione, P.; Piekny, A. A Novel Microtubule-Targeting Compound that Disrupts Mitotic Spindle Poles in Human Cells, Scientific Reports. 2021, 11, 23665. DOI
Liu, J.T.; Jaunky, D.B.; Larocque, K.; Chen, F.; Mckibbon, K.; Sirouspour, M.; Taylor, S.; Shafeii, A.; Campbell, D.; Braga, H.; Piekny, A.; Forgione, P. Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent, Bioorg. Med. Chem. Lett. 2021, 52, 128327. DOI (10.1016/j.bmcl.2021.128327)
Messina, C.; Ottenwaelder, X.; Forgione, P. Programmed Synthesis of Tetra-Aryl Thiophenes with Stepwise, Ester-Controlled Regioselectivity, Org. Lett. 2021, 23, 7348. DOI (10.1021/acs.orglett.1c02447)
Chacón-Huete, F.; Lasso, J.D.; Szavay, P.; Covone, J.; Forgione, P. Synthesis of 2,5-Diaryl Nonsymmetric Furans C6-Platform Chemicals via Catalytic Conversion of Biomass and the Formal Synthesis of Dantrolene, J. Org. Chem. 2021, 86, 515. DOI (10.1021/acs.joc.0c02236)
Messina, C.; Douglas, L.Z.; Liu, J.T.; Forgione, P. Successive Pd-Catalyzed Decarboxylative Cross-Couplings for the Modular Synthesis of Non-Symmetric Di-Aryl-Substituted Thiophenes, Eur. J. Org. 2020, 32, 1434. DOI (https://doi.org/10.1002/ejoc.202000780)
Costa Franca, T.C; Costa Bastos, L.; Cuya, T.; Sirouspour, M.; Chacón-Huete, F.; Bendahan, D.; Forgione, P. Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis, Letters in Drug Design & Discovery, 2020, 17, 633. DOI (https://dx.doi.org/10.2174/1570180816666190710144212)
Liu, J. T.; Hase, H.; Taylor, S.; Salzmann, I.; Forgione, P. Approaching the Interger-Charge Transfer Regime in Molecularly Doped Oligothiophenes by Efficient Decarboxylative Cross-Coupling, Angew. Chem. Int. Ed. 2020, 59, 7146. DOI
Bastos, L.; Rodrigues de Souza, F.; Souza, L.; Forgione, P.; Cuya, T.; Bicca de Alencastro, R.; Pimentel, A.S.; Franca, T. Investigating the Selectivity of Potential New Inhibitors of Dihydrofolate Reductase from Yersinia Pestis Designed by Molecular Modeling, J. Biomol. Struct. Dynam. 2019, 37, 1170. DOI (https://doi.org/10.1080/07391102.2018.1452796)
Liang, Y.; Manioudakis, J.; Macairan, J-R.; Askari, M.S.; Forgione, P.; Naccache, R. Facile Aqueous-Phase Synthesis of an Ultrasmall Bismuth Nanocatalyst for the Reduction of 4-Nitrophenol, ACS Omega. 2019, 4, 14955. DOI
Zhang, X.; Chen, F.; Petrella, A.; Chacón-Huete, F.; Covone, J.; Tsai, T-W.; Yu, C-C.; Forgione, P.; Kwan, D.H. A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification, ACS Chem. Biol. 2019, 14, 715. DOI (https://dx.doi.org/10.1021/acschembio.8b01123)
Chacón-Huete, F.; Messina, C.; Chen, F.; Cuccia, L.; Ottenwaelder, X.; Forgione, P. Solvent-free mechanochemical oxidation and reduction of biomass-derived 5-hydroxymethyl furfural, Green Chem. 2018, 20, 5261. DOI (https://dx.doi.org/10.1039/c8gc02481b)
Chen, F.; Chacón-Huete, F.; Hassan, E-H.; Forgione, P. Convenient and Inexpensive Route to Sulfonylated Pyridines via SNAr Reaction of Electron-Rich Pyridines by Iron Catalysis, Synthesis. 2018, 50, 1914. DOI (https://dx.doi.org/10.1055/s-0036-1591541)
Patents
Forgione, P.; Piekny, A.J.; Jaunky, D.B.; Chen, F.; Liu J.T., Thienoisoquinolines and their derivatives for the treatment of cancer, PCT Int. Appl. (2020), 67 pp. US 20200024284 Link
Forgione, P.; Piekny, A.J.; Larocque, K.; Jaunky, D.B.; Chen, F.; Liu J.T., Thienoisoquinolines and their derivatives for targeting tubulin, ch-TOG, Aurora A kinase, TPX2, Cdk5rap2 and/or ASPM, PCT Int. Appl. (2020), 93 pp. US 20200276181 Link
Stammers, T.; Barbeau, X.; Beaulieu, P.; Bertrand-Laperle, M.; Brochu, C.; Edwards, P.J.; Forgione, P.; Godbout, C.; Hucke, O.; Joly, M.-A. Landry, S.; Lepage, O.; Naud, J.; Pesant, M.; Poirier, M.; Poirier, M.; Thavonekham, B., Quinazolinone derivatives as viral polymerase inhibitors and their preparation and use in the treatment of hepatitis C viral infection, PCT Int. Appl. (2011), 203 pp. WO 2011032277 Link
Beaulieu, P.; Bonneau, P.; Coulombe, R.; Forgione, P.; Gillard, J.; Jakalian, A.; Rancourt, J., Viral polymerase inhibitors, PCT Int. Appl. (2010), 139 pp. WO 201037210 Link
Beaulieu, P.L.; Forgione, P.; Gagnon, A.; Godbout, C.; Joly, M.-A.; Llinas-Brunet, M.; Naud, J.; Poirier, M.; Rancourt, J., Preparation of 2-amido benzoic acid compounds as viral polymerase inhibitors, PCT Int. Appl. (2009), 236 pp. WO 2009076747 Link
Beaulieu, P.L.; Forgione, P.; Gagnon, A.; Godbout, C.; Naud, J.; Poirier, M.; Racourt, J.; Stammers, T.A.; Thavonekham, B., Preparation of substituted carbonylaminobenzoic acid for use as viral polymerase inhibitors, PCT Int. Appl. (2009), 170 pp. WO 2009018656 Link
Bailey, M.D.; Bilodeau, F.; Forgione, P.; Gorys, V.; Llinas-Brunet, M.; Naud, J.; O'Meara, J.; Poupart, M.-A., Preparation of peptides as inhibitors of hepatitis C virus NS3 protease, PCT Int. Appl. (2008), 94 pp. WO 2008098368 Link
Bailey, M. D.; Forgione, P.; Llinas-Brunet, M.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, PCT Int. Appl. (2007), 64 pp. WO 2007009227 Link
Bailey, M. D.; Bhardwaj, P.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Llinas-Brunet, M.; Poupart, M.-A.; Rancourt, J., Preparation of Peptide Analogs as Hepatitis C Inhibitors, PCT Int. Appl. (2006), 162 pp. WO 2006000085 Link
Llinas-Brunet, M.; Bailey, M.; Bhardwaj, P.; Bilodeau, F.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Rancourt, J., Macrocyclic Peptides Active Against the Hepatitis C Virus, PCT Int. Appl. (2005), 119 pp. WO 2005070955 Link
Llinas-Brunet, M.; Bailey, M.; Bhardwaj, P.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Rancourt, J., Preparation of Macrocyclic Peptides Active Against the Hepatitis C Virus, PCT Int. Appl. (2005), 128 pp. WO 2005028501 Link
Bailey, M.; Bilodeau, F.; Forgione, P.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, Pct Int. Provisional Appl. (2005), 78 pp. 13/140 PV (withdrawn, strategic decision)
Bailey, M.; Bhardwaj, P.; Bilodeau, F.; Cameron, D.; Forgione, P.; Halmos, T.; Naud, J.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, Pct Int. Appl. (2005), 149 pp. 13/129 WO (withdrawn, strategic decision)
Llinas-Brunet, M.; Bailey, M. D.; Bhardwaj, P.; Bordeleau, J.; Forgione, P.; Ghiro, E.; Gorys, V.; Goudreau, N.; Goulet, S.; Halmos, T.; Rancourt, J., Preparation of Heterocyclic Peptides as Hepatitis C Inhibitors, PCT Int. Appl. (2004), 186 pp. WO 2004103996 Link