RESEARCH

Stimuli-responsive degradation (SRD) or cleavage of dynamic covalent bonds in response to external stimuli is a promising platform for the development of polymer-based multifunctional nanomaterials. These nanomaterials are designed to degrade upon the cleavage of dynamic linkages in response to single or multi-stimuli. With our focus on promising disulfide-based redox chemistry as an initial thrust, our group has developed a variety of reduction-responsive degradable nanomaterials, which have allowed for tuning lower critical solution temperature, controlling nanoparticle morphologies, fabricating sheddable fibers, and enhancing controlled drug release.