David M. Secko, PhD
Professor, Journalism
Biography Selected publications Selected conference papers and presentations Learn more about Dr. Secko and his work Prospective graduate students Formation of the Concordia Science Journalism Project
| Email: | david.secko@concordia.ca |
| Website(s): |
CSJP Projected Futures |
| Availability: |
Please email me. |
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Biography
Previously worked as a science journalist for The Scientist magazine, Vancouver’s Tyee, the Science Creative Quarterly, Canadian Medical Association Journal and the U.S. Public Library of Science (PLoS). Dr. Secko now studies the future of science journalism. He is the leader of the Concordia Science Journalism Project and our experiential science journalism summer school Projected Futures.
Education
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Postdoctoral Fellow, W. Maurice Young Centre for Applied Ethics, University of British Columbia
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PhD, Microbiology and Immunology, University of British Columbia
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MJ (Science Journalism), University of British Columbia
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BSc (Hons.), Life Science, Queen’s University
Areas of research interest
I am currently the MA Program Director in the Department of Journalism with a diverse research team working on digital innovation related to how science is communicated with society through journalism.
Before turning to journalism, I was trained as a molecular biologist at the University of British Columbia. This research focused on the soil amoeba Dictyostelium discoideum and efforts to understand how it was capable of living a solitary life until starved, where upon it signaled to its kin to organize into a multicellular organism and crawl together to a new source of food. I followed this up with adventures as a science journalist.
At Concordia University, my team works to give journalists and students new tools to communicate science. We are particularly interested in experimental science journalism and innovating with new forms of scientific storytelling. This research seeks to link across journalism, science and ethical issues to clarify and experiment with the roles of publics, experts and journalists in the democratic governance of biotechnology. Examples of our work include examining educational visions for the future of science journalism, the definition and testing of four models of science journalism, and a metasynthesis of the experiences of science journalists. We also study the moderation and design of deliberative engagement events.
This research has won a University Research Award and a Dean’s Award for Excellence. It is put into practice through our summer school, Projected Futures.
Courses taught
JOUR 645 Projected Futures: Experimental Science Journalism Studies
JOUR 500 Critical Approaches to Journalism
JOUR 402 Specialist Reporting: Science
JOUR 205 Principles of Journalistic Thought
Selected publications
Publications since 2000
1M. A. A. Orabi, E. A. Orabi, E. Abdel-SattarE, H. Sakagami, A. M. English, T. Hatano and H. Elimam (2023) Structuraldetermination and anticholinesterase assay of C-glycosidic ellagitannins from Lawsoniainermis leaves: A study supported by DFT calculations and molecular docking,Fitoterapia 164, 105360. https://doi.org/10.1016/j.fitote.2022.105360
2. E.A. Orabi and A.M. English (2020) ModelingShows that Rotation About the Peroxide O-O bond Assists Protein and LipidFunctional Groups in Discriminating Between H2O2 and H2O,J. Phys. Chem. B. 125, 137-147. https://doi.org/10.1016/j.molliq.2021.115469
3. D. Martins, G.A. McKay, A.M. English, D.Nguyen (2020) Sublethal paraquat confers multidrug tolerance inPseudomonas aeruginosa by inducing superoxide dismutase activity and loweringenvelope permeability, Front. Microbiol. 11:576708. https://doi.org/10.3389/fmicb.2020.576708
4. S. Dastpeyman, R. Godin, G. Cosa and A.M.English (2020) Quantifying Heme-Protein Maturation from RatiometricFluorescence Lifetime Measurements on the Single Fluorophore in Its GFP Fusion,J. Phys. Chem. A, 124, 746-754. https://doi.org/10.1021/acs.jpca.9b11901
5. E.A. Orabi and A.M. English (2019) Expandingthe range of binding energies and oxidizability of biologically relevantS-aromatic interactions: Imidazolium and phenolate binding to sulfoxide andsulfone, Phys. Chem. Chem. Phys. 21, 14620-14628. https://doi.org/10.1039/C9CP02332A
6. D.Martins, D. Nguyen and A.M. English (2019) Ctt1 catalase activitypotentiates antifungal azoles in the emerging opportunistic pathogenSaccharomyces cerevisiae, Nature Sci Reports. 9, 9185-9195. https://doi.org/10.1038/s41598-019-45070-w
7. M. Kathiresan and A.M. English (2018)LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidationin mitochondria and functionally important hole hopping from its heme, J.Am. Chem. Soc. 140, 12033-12039. https://doi.org/10.1021/jacs.8b05966
8. E.A.Orabi and A.M. English (2018) Predicting structural and energeticchanges in Met-aromatic motifs on methionine oxidation to the sulfoxide andsulfone, Phys. Chem. Chem. Phys. 20, 23132-23141. https://doi.org/10.1039/C8CP03277G
9. D. Martins, G. Sampathkumar, G. McKay, M.Khakimova, A.M. English and D. Nguyen (2018) Superoxide dismutaseactivity confers (p)ppGpp-mediated antibiotic tolerance to stationary phasePseudomonas aeruginosa, Proc. Nat. Acad. Sci, USA 115, 9797-9802. https://doi.org/10.1073/pnas.1804525115
M. Kathiresan and A.M. English (2018) LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidation in mitochondria and functionally important hole hopping from its heme, J. Am. Chem. Soc. 140, 12033-12039.
E.A. Orabi and A.M. English (2018) Predicting structural and energetic changes in Met-aromatic motifs on methionine oxidation to the sulfoxide and sulfone, Phys. Chem. Phys. 20, 23132 – 23141.
D. Martins, G. Sampathkumar, G. Mckay, M. Khakimova, A.M. English and D. Nguyen (2018) Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary phase Pseudomonas aeruginosa, Proc. Nat. Acad. Sci, USA 115, 9797–9802.
E.A. Orabi and A.M. English (2018) A Simple Additive Potential Model for Simulating Hydrogen Peroxide in Chemical and Biological Systems, J. Chem. Theory Comput. 14, 2808–2821.
E.A. Orabi and A.M. English (2018) Modeling protein S-aromatic motifs reveals their structural and redox flexibility, J. Phys Chem. B 122, 3760–3770.
S. Jahangiri, Q.K. Timerghazin, H. Jiang, G.H. Peslherbe and A.M. English (2018) Dramatic C–C Bond Activation on Protonation of the Persistent Nitroxyl Radical TEMPO•, Int. J. Mass Spectrom. 429, 182-188 (Festschrift for T.B.McMahon).
M. Kathiresan and A.M. English (2017) LC-MS/MS reveals that hole hopping in cytochrome c peroxidaseprotects its heme from oxidative modification by excess H2O2, Chem. Sci. 8, 1152-1162.
P. Ponka, A.D. Sheftel, A.M. English, D.S. Bohle and D. Garcia-Santosa (2017) Do mammalian cells really need to export and import heme? Trends Biochem. Sci. 42, 395-406.
E.A. Orabi and A.M. English (2016) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Binding toTyrosinate and Histidinium Ions to Assess Their Influence on Protein Electron Transfer, Isr. J. Chem. 56, 872-885 (Festschrift for H.B. Gray).
M. Kathiresan and A.M. English (2016) Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: Implications in stress response and heme trafficking, Metallomics 8, 434 -443.
M.S. Shadrina, A.M. English and G.H. Peslherbe (2016) Benchmarking Rapid TLES Simulations of Gas Diffusion in Proteins: Mapping O2 Migration and Escape in Myoglobin as a Case Study, J. Chem. Theory Comput. 12, 2038-2046.
M.S. Shadrina, G.H. Peslherbe and A.M. English (2015) Quaternary-linked changes in structure and dynamics that modulate O2 migration within hemoglobin’s gas diffusion tunnels, Biochemistry 54, 5268-5278.
M.S. Shadrina, G.H. Peslherbe and A.M. English (2015) O2 and water migration pathways between the solvent and heme pockets of hemoglobin with open and closed conformations of the distal HisE7, Biochemistry 54, 5279-5289.
D. Martins and A.M. English (2015) Peroxynitrite and hydrogen peroxide elicit a similar cellular stress response mediated by the Ccp1 sensor protein, Free Rad. Biol. Med. 85, 138-147.
M. Kathiresan, D.Martins and A.M. English (2014) Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria, Proc. Nat. Acad. Sci, USA 111, 17468-7473.
D. Martins and A.M. English (2014) Sod1 oxidation and formation of soluble aggregates in yeast: relevance to sporadic ALS development, Redox Biology 2, 632-639.
D. Martins, V.I. Titorenko and A.M. English (2014) Cells with impaired mitochondrial H2O2sensing generate less OH radicals and live longer, Antiox. Red. Sig. 21, 1490-1503.
D. Martins and A.M. English (2014) catalase activity is stimulated by H2O2 in rich culture medium and is required for H2O2 resistance and adaptation in yeast, Redox Biology 2, 308-313.
B. Shen, C. Bazin and A.M English (2013) Rapid high-yield N-acetylation of aminothiols: N-acetylglutathione and N-acetylhomocysteine and their thiol pKa values, J. Peptide Science 19, 263-267.
A. Clarke, M. Ouellet and A.M. English (2013) Overcoming matrix effects in the chemiluminescence determination of extracellular adenosine triphosphate in erythrocyte suspensions, Anal. Biochem. 436, 66-68.
M. Khakimova, H.G. Ahlgren, J.J. Harrison, A.M. English and D. Nguyen (2013) The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance, J. Bacteriology 195, 2011-2020.
D. Martins, M. Kathiresan and A.M. English (2013) Cytochrome c peroxidase (Ccp1) is a mitochondrial heme-based H2O2 sensor that modulates antioxidant defense, Free Rad. Biol. Med. 65, 541-551.
A.B. Seabra, M. Ouellet, M. Antonic, M.N. Chrétien and A.M. English (2013) Catalysis of nitrite generation from nitroglycerin by glyceraldehyde-3-phosphatedehydrogenase (GAPDH), Nitric Oxide 35, 116-122.
M.S. Shadrina, A.M. English and G.H. Peslherbe (2012) Effective simulations of gas diffusion through kinetically accessible tunnels in multi-subunit proteins: O2 pathways and escape routes in T-state deoxyhemoglobin, J. Am. Chem. Soc. 134, 11177-11184.
D. Susanto, A.M. English, R.Sharma and E. Kwong (2011) An alternative approach using ESI-MS to iron quantitation in pharmaceutical formulations containing iron oxide, J. Mass Spec. 46, 508-516.
E.E. Moran, Q.K. Timerghazin, E. Kwong and A.M. English (2011) Kinetics and mechanism of S‑nitrosothiol acid-catalyzed hydrolysis: Sulfur activation promotes facile NO release, J. Phys. Chem. B 115, 3112-3126.
J.I. Garcia, A.B. Seabra, R. Kennedy and A.M. English (2010) Nitrite and nitroglycerin induce rapid release of the vasodilator ATP from erythrocytes: Relevance to the chemical physiology of local vasodilation, J. Inorg. Biochem. 104, 289-296.
A.A. Goldberg, V.R. Richard, P. Kyryakov, S.D. Bourque, A. Beach, M.T. Burstein, A. Glebov, O. Koupaki, T. Boukh-Viner, C. Gregg, M. Juneau, A.M. English, D.Y. Thomas and V.I. Titorenko (2010) Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes, Aging 2, 393-414.
Q.K. Timerghazin, G.H. Peslherbe and A.M. English (2008) Structure and stability of HSNO, the simplest S-nitrosothiol, Phys. Chem. Chem. Phys. 10, 1532-1539.
Q.K. Timerghazin, A.M. English and G.H. Peslherbe (2008) On the multi-reference character of S-nitrosothiols, Chem. Phys. Letts. 454, 24-29.
Q.K. Timerghazin, G.H. Peslherbe and A.M. English (2007) Resonance description of S-nitrosothiols: Insights into reactivity, Org. Letts. 9, 3049-3052.
J. Laterreur and A.M. English (2007) Hemoglobin S-nitrosation on oxygenation of nitrite deoxyhemoglobin incubations is attenuated by methemoglobin, J. Inorg. Biochem. 101, 1827-1835.
J.-F. Roy, M.N. Chrétien, B. Woodside and A.M.English (2007) Reduction and S-nitrosation of the neuropeptide oxytocin: Implications for its biological function, Nitric Oxide 17, 82-90.
M. Ye and A.M. English (2006) Binding of polyaminocarboxylate chelators to the active-site copper inhibits the GSNO-reductase activity but not the superoxide dismutase activity of Cu,Zn-superoxide dismutase, Biochemistry 45, 12723-12732.
H. Jiang and A.M. English (2006) Phenotypic analysis of the ccp1D and ccp1D-ccp1W191F mutant strains of Saccharomyces cerevisiae indicates that cytochrome c peroxidase functions inoxidative-stress signalling, J. Inorg. Biochem. 100, 1996-2008.
H. Jiang and A.M. English (2006) Evaluation of D10-Leu metabolic labeling coupled with MALDI-MS analysis in studying the response of the yeast proteome to H2O2challenge, J. Proteome Res. 5, 2539-2546.
B. Shen, J.C. Scaiano, and A.M. English (2006) Zeolite encapsulation decreases TiO2-photosensitized ROS generation in cultured human skin fibroblasts, Photochem. Photobiol. 82, 5-12.
B. Shen and A.M.English (2005) Mass spectrometric analysis of nitroxyl-mediated protein modification: comparison of products formed with free and protein-based cysteines, Biochemistry 44, 14030-14044.
T. Boukh-Viner, T. Guo, A. Alexandrian, A. Cerracchio, C. Gregg, S. Haile, R. Kyskan, S. Milijevic, D. Oren, J. Solomon, V. Wong, J.M. Nicaud, R.A. Rachubinski, A.M. English and V.I. Titorenko (2005) Dynamic ergosterol-and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion, J. Cell Biol. 168, 761-773.
H. Bard, A.M. English, C. Gagnon and K. Bellemin (2005) The effect of adult hemoglobin on red blood cell nitric oxide levels during fetal development, Biol. Neonate 87,203-206.
M.N. Chretien, B. Shen, H. Garcia, A.M. English and J.C. Scaiano (2004) Ship-in-a-bottle synthesis of fluorescence-labeled nanoparticles: applications in cellular imaging, Photochem. Phtotobiol. 40, 434-437.
H. Bard, A. M. English, K. Bellemin and C. Gagnon (2004) Developmental changes in NO bioavailability in fetal erthrocytes, Semin. Perinatol. 28,312-316.
M. Ouellet, S. M. Aitken, A. M. English and M. D. Percival (2004) Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin synthase-2, Arch. Biochem. Biophys. 431,107-118.
L. Tao and A.M. English (2004) Protein S-glutathiolation triggered by decomposed S-nitrosoglutathione, Biochemistry 43, 4228-4038.
S.M. Aitken, M. Ouellet, M. D. Percival and A. M. English (2003) Mechanism of horseradish peroxidase inactivation by benzhydrazide: a critical evaluation of arylhydrazides as peroxidase inhibitors, Biochem. J. 375, 613-621.
A.A. Romeo, J.A. Capobianco and A.M. English (2003) Superoxide dismutase targets NO from GSNO to Cysb93 of oxyhemoglobin in concentrated but not dilute solutions of the protein, J. Am. Chem. Soc. 125,14370-14378.
P. J. Wright and A.M. English (2003) Scavenging with TEMPO• to identify peptide-and protein-based radicals by mass spectrometry: Advantages of spin scavenging over spin trapping, J. Am. Chem. Soc. 125, 8655-8665.
R. Papp, I. Ekiel and A.M. English (2003) ESI-MS and FTIR studies of the interaction between the second PDZ domain of hPTP1E and target peptides, Biochem. Cell Biol. 81, 71-80.
L. Tao and A.M. English (2003) Mechanism of S-nitrosation of recombinant human brain calbindin D28K, Biochemistry 42, 3326-3334.
G. Tsaprailis and A.M. English (2003) Mass spectral analysis of tyrosyl radicals generated in yeast cytochrome c peroxidase and its W191F mutant on reaction with H2O2, J. Biol. Inorg. Chem. 8, 248-255.
C. Toubin, D. Y.-H. Yeung, A.M. English and G.H. Peslherbe (2002) Theoretical Investigations of S-nitrosothiol Degradation: Probing the Catalytic Role of Copper Ions, J. Am. Chem. Soc. (Chem. Comm.) 124, 14816-1481.
J. Heng and A. M. English (2002) Quantitative Analysis of the Yeast Proteome by Incorporation of Labeled Leucine, J. Proteome Res. 1, 345-350.
A.A. Romeo, J.A. Capobianco and A.M. English (2002) Reaction of deoxyhemoglobin with S-nitrosogluthatione requires copper, J. Biol. Chem. 277, 24135-24141.
L. Tao, M.E.P. Murphy and A.M. English (2002) S-Nitrosation of Ca-loaded and Ca-free recombinant calbindin D28K from human brain, Biochemistry 41, 6185-6192.
S. Akhter, A. Vignini, Z. Wen, A.M. English, P.G. Wang and B. Mutus (2002) Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation, Proc. Natl. Acad. USA 99, 9172-9177.
S. M. Aitken, J.L. Turnbull, M.D. Percival and A.M. English (2001) Thermodynamic analysis of the binding of aromatic hydroxamic acid analogs to ferric horseradish peroxidase, Biochemistry 40, 13980-13989.
A. Filosa, Y. Wang, A.A. Ismail and A.M. English (2001) Two-dimensional correlation spectroscopy as a probe of the sequential events in the thermal unfolding of cytochromes c, Biochemistry 40, 8256-8263.
D.E. Wilcox and A.M. English (2001) Effects of metal ions on the oxidation and nitration of cysteine residues in proteins and enzymes, Eds. A. Sigel and H. Sigel, Metal Ions in Biological Systems, Vol 38. Marcel Dekker, New York, pp 313-350.
A. Filosa and A.M. English (2001) Mass spectral analysis of protein-based radicals using DBNBS: Non-radical adduct formation vs spin trapping, J. Biol. Chem. 276, 21022-21027.
P.J. Wright and A.M. English (2001) Buffer anions promote leaching of Ca from horseradish peroxidase at low pH: Possible shielding role of carbohydrate, J. Biol. Inorg. Chem. 6, 348-358.
A.A. Romeo, A. Filosa, J.A. Capobianco and A.M. English (2001) Metal chelators inhibit S-nitrosation of Cysb93 in oxyhemoglobin, J. Am. Chem. Soc. (Chem. Comm) 123, 1782-1783.
A. Filosa and A.M. English (2000) Probing local thermal stabilities of bovine, horse and tuna ferricytochromes c at pH 7, J. Biol. Inorg. Chem. 5, 448-454.Selected conference papers and presentations
Learn more about Dr. Secko and his work
Analytical chemistry, bioinorganic chemistry, biophysical chemistry, cell signalling, chemical kinetics, electron and proton transfer in chemistry and biology, mass spectrometry, protein chemistry and proteomics.
Prospective graduate students
Formation of the Concordia Science Journalism Project
Publications since 2000
1M. A. A. Orabi, E. A. Orabi, E. Abdel-SattarE, H. Sakagami, A. M. English, T. Hatano and H. Elimam (2023) Structuraldetermination and anticholinesterase assay of C-glycosidic ellagitannins from Lawsoniainermis leaves: A study supported by DFT calculations and molecular docking,Fitoterapia 164, 105360. https://doi.org/10.1016/j.fitote.2022.105360
2. E.A. Orabi and A.M. English (2020) ModelingShows that Rotation About the Peroxide O-O bond Assists Protein and LipidFunctional Groups in Discriminating Between H2O2 and H2O,J. Phys. Chem. B. 125, 137-147. https://doi.org/10.1016/j.molliq.2021.115469
3. D. Martins, G.A. McKay, A.M. English, D.Nguyen (2020) Sublethal paraquat confers multidrug tolerance inPseudomonas aeruginosa by inducing superoxide dismutase activity and loweringenvelope permeability, Front. Microbiol. 11:576708. https://doi.org/10.3389/fmicb.2020.576708
4. S. Dastpeyman, R. Godin, G. Cosa and A.M.English (2020) Quantifying Heme-Protein Maturation from RatiometricFluorescence Lifetime Measurements on the Single Fluorophore in Its GFP Fusion,J. Phys. Chem. A, 124, 746-754. https://doi.org/10.1021/acs.jpca.9b11901
5. E.A. Orabi and A.M. English (2019) Expandingthe range of binding energies and oxidizability of biologically relevantS-aromatic interactions: Imidazolium and phenolate binding to sulfoxide andsulfone, Phys. Chem. Chem. Phys. 21, 14620-14628. https://doi.org/10.1039/C9CP02332A
6. D.Martins, D. Nguyen and A.M. English (2019) Ctt1 catalase activitypotentiates antifungal azoles in the emerging opportunistic pathogenSaccharomyces cerevisiae, Nature Sci Reports. 9, 9185-9195. https://doi.org/10.1038/s41598-019-45070-w
7. M. Kathiresan and A.M. English (2018)LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidationin mitochondria and functionally important hole hopping from its heme, J.Am. Chem. Soc. 140, 12033-12039. https://doi.org/10.1021/jacs.8b05966
8. E.A.Orabi and A.M. English (2018) Predicting structural and energeticchanges in Met-aromatic motifs on methionine oxidation to the sulfoxide andsulfone, Phys. Chem. Chem. Phys. 20, 23132-23141. https://doi.org/10.1039/C8CP03277G
9. D. Martins, G. Sampathkumar, G. McKay, M.Khakimova, A.M. English and D. Nguyen (2018) Superoxide dismutaseactivity confers (p)ppGpp-mediated antibiotic tolerance to stationary phasePseudomonas aeruginosa, Proc. Nat. Acad. Sci, USA 115, 9797-9802. https://doi.org/10.1073/pnas.1804525115
M. Kathiresan and A.M. English (2018) LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidation in mitochondria and functionally important hole hopping from its heme, J. Am. Chem. Soc. 140, 12033-12039.
E.A. Orabi and A.M. English (2018) Predicting structural and energetic changes in Met-aromatic motifs on methionine oxidation to the sulfoxide and sulfone, Phys. Chem. Phys. 20, 23132 – 23141.
D. Martins, G. Sampathkumar, G. Mckay, M. Khakimova, A.M. English and D. Nguyen (2018) Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary phase Pseudomonas aeruginosa, Proc. Nat. Acad. Sci, USA 115, 9797–9802.
E.A. Orabi and A.M. English (2018) A Simple Additive Potential Model for Simulating Hydrogen Peroxide in Chemical and Biological Systems, J. Chem. Theory Comput. 14, 2808–2821.
E.A. Orabi and A.M. English (2018) Modeling protein S-aromatic motifs reveals their structural and redox flexibility, J. Phys Chem. B 122, 3760–3770.
S. Jahangiri, Q.K. Timerghazin, H. Jiang, G.H. Peslherbe and A.M. English (2018) Dramatic C–C Bond Activation on Protonation of the Persistent Nitroxyl Radical TEMPO•, Int. J. Mass Spectrom. 429, 182-188 (Festschrift for T.B.McMahon).
M. Kathiresan and A.M. English (2017) LC-MS/MS reveals that hole hopping in cytochrome c peroxidaseprotects its heme from oxidative modification by excess H2O2, Chem. Sci. 8, 1152-1162.
P. Ponka, A.D. Sheftel, A.M. English, D.S. Bohle and D. Garcia-Santosa (2017) Do mammalian cells really need to export and import heme? Trends Biochem. Sci. 42, 395-406.
E.A. Orabi and A.M. English (2016) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Binding toTyrosinate and Histidinium Ions to Assess Their Influence on Protein Electron Transfer, Isr. J. Chem. 56, 872-885 (Festschrift for H.B. Gray).
M. Kathiresan and A.M. English (2016) Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: Implications in stress response and heme trafficking, Metallomics 8, 434 -443.
M.S. Shadrina, A.M. English and G.H. Peslherbe (2016) Benchmarking Rapid TLES Simulations of Gas Diffusion in Proteins: Mapping O2 Migration and Escape in Myoglobin as a Case Study, J. Chem. Theory Comput. 12, 2038-2046.
M.S. Shadrina, G.H. Peslherbe and A.M. English (2015) Quaternary-linked changes in structure and dynamics that modulate O2 migration within hemoglobin’s gas diffusion tunnels, Biochemistry 54, 5268-5278.
M.S. Shadrina, G.H. Peslherbe and A.M. English (2015) O2 and water migration pathways between the solvent and heme pockets of hemoglobin with open and closed conformations of the distal HisE7, Biochemistry 54, 5279-5289.
D. Martins and A.M. English (2015) Peroxynitrite and hydrogen peroxide elicit a similar cellular stress response mediated by the Ccp1 sensor protein, Free Rad. Biol. Med. 85, 138-147.
M. Kathiresan, D.Martins and A.M. English (2014) Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria, Proc. Nat. Acad. Sci, USA 111, 17468-7473.
D. Martins and A.M. English (2014) Sod1 oxidation and formation of soluble aggregates in yeast: relevance to sporadic ALS development, Redox Biology 2, 632-639.
D. Martins, V.I. Titorenko and A.M. English (2014) Cells with impaired mitochondrial H2O2sensing generate less OH radicals and live longer, Antiox. Red. Sig. 21, 1490-1503.
D. Martins and A.M. English (2014) catalase activity is stimulated by H2O2 in rich culture medium and is required for H2O2 resistance and adaptation in yeast, Redox Biology 2, 308-313.
B. Shen, C. Bazin and A.M English (2013) Rapid high-yield N-acetylation of aminothiols: N-acetylglutathione and N-acetylhomocysteine and their thiol pKa values, J. Peptide Science 19, 263-267.
A. Clarke, M. Ouellet and A.M. English (2013) Overcoming matrix effects in the chemiluminescence determination of extracellular adenosine triphosphate in erythrocyte suspensions, Anal. Biochem. 436, 66-68.
M. Khakimova, H.G. Ahlgren, J.J. Harrison, A.M. English and D. Nguyen (2013) The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance, J. Bacteriology 195, 2011-2020.
D. Martins, M. Kathiresan and A.M. English (2013) Cytochrome c peroxidase (Ccp1) is a mitochondrial heme-based H2O2 sensor that modulates antioxidant defense, Free Rad. Biol. Med. 65, 541-551.
A.B. Seabra, M. Ouellet, M. Antonic, M.N. Chrétien and A.M. English (2013) Catalysis of nitrite generation from nitroglycerin by glyceraldehyde-3-phosphatedehydrogenase (GAPDH), Nitric Oxide 35, 116-122.
M.S. Shadrina, A.M. English and G.H. Peslherbe (2012) Effective simulations of gas diffusion through kinetically accessible tunnels in multi-subunit proteins: O2 pathways and escape routes in T-state deoxyhemoglobin, J. Am. Chem. Soc. 134, 11177-11184.
D. Susanto, A.M. English, R.Sharma and E. Kwong (2011) An alternative approach using ESI-MS to iron quantitation in pharmaceutical formulations containing iron oxide, J. Mass Spec. 46, 508-516.
E.E. Moran, Q.K. Timerghazin, E. Kwong and A.M. English (2011) Kinetics and mechanism of S‑nitrosothiol acid-catalyzed hydrolysis: Sulfur activation promotes facile NO release, J. Phys. Chem. B 115, 3112-3126.
J.I. Garcia, A.B. Seabra, R. Kennedy and A.M. English (2010) Nitrite and nitroglycerin induce rapid release of the vasodilator ATP from erythrocytes: Relevance to the chemical physiology of local vasodilation, J. Inorg. Biochem. 104, 289-296.
A.A. Goldberg, V.R. Richard, P. Kyryakov, S.D. Bourque, A. Beach, M.T. Burstein, A. Glebov, O. Koupaki, T. Boukh-Viner, C. Gregg, M. Juneau, A.M. English, D.Y. Thomas and V.I. Titorenko (2010) Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes, Aging 2, 393-414.
Q.K. Timerghazin, G.H. Peslherbe and A.M. English (2008) Structure and stability of HSNO, the simplest S-nitrosothiol, Phys. Chem. Chem. Phys. 10, 1532-1539.
Q.K. Timerghazin, A.M. English and G.H. Peslherbe (2008) On the multi-reference character of S-nitrosothiols, Chem. Phys. Letts. 454, 24-29.
Q.K. Timerghazin, G.H. Peslherbe and A.M. English (2007) Resonance description of S-nitrosothiols: Insights into reactivity, Org. Letts. 9, 3049-3052.
J. Laterreur and A.M. English (2007) Hemoglobin S-nitrosation on oxygenation of nitrite deoxyhemoglobin incubations is attenuated by methemoglobin, J. Inorg. Biochem. 101, 1827-1835.
J.-F. Roy, M.N. Chrétien, B. Woodside and A.M.English (2007) Reduction and S-nitrosation of the neuropeptide oxytocin: Implications for its biological function, Nitric Oxide 17, 82-90.
M. Ye and A.M. English (2006) Binding of polyaminocarboxylate chelators to the active-site copper inhibits the GSNO-reductase activity but not the superoxide dismutase activity of Cu,Zn-superoxide dismutase, Biochemistry 45, 12723-12732.
H. Jiang and A.M. English (2006) Phenotypic analysis of the ccp1D and ccp1D-ccp1W191F mutant strains of Saccharomyces cerevisiae indicates that cytochrome c peroxidase functions inoxidative-stress signalling, J. Inorg. Biochem. 100, 1996-2008.
H. Jiang and A.M. English (2006) Evaluation of D10-Leu metabolic labeling coupled with MALDI-MS analysis in studying the response of the yeast proteome to H2O2challenge, J. Proteome Res. 5, 2539-2546.
B. Shen, J.C. Scaiano, and A.M. English (2006) Zeolite encapsulation decreases TiO2-photosensitized ROS generation in cultured human skin fibroblasts, Photochem. Photobiol. 82, 5-12.
B. Shen and A.M.English (2005) Mass spectrometric analysis of nitroxyl-mediated protein modification: comparison of products formed with free and protein-based cysteines, Biochemistry 44, 14030-14044.
T. Boukh-Viner, T. Guo, A. Alexandrian, A. Cerracchio, C. Gregg, S. Haile, R. Kyskan, S. Milijevic, D. Oren, J. Solomon, V. Wong, J.M. Nicaud, R.A. Rachubinski, A.M. English and V.I. Titorenko (2005) Dynamic ergosterol-and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion, J. Cell Biol. 168, 761-773.
H. Bard, A.M. English, C. Gagnon and K. Bellemin (2005) The effect of adult hemoglobin on red blood cell nitric oxide levels during fetal development, Biol. Neonate 87,203-206.
M.N. Chretien, B. Shen, H. Garcia, A.M. English and J.C. Scaiano (2004) Ship-in-a-bottle synthesis of fluorescence-labeled nanoparticles: applications in cellular imaging, Photochem. Phtotobiol. 40, 434-437.
H. Bard, A. M. English, K. Bellemin and C. Gagnon (2004) Developmental changes in NO bioavailability in fetal erthrocytes, Semin. Perinatol. 28,312-316.
M. Ouellet, S. M. Aitken, A. M. English and M. D. Percival (2004) Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin synthase-2, Arch. Biochem. Biophys. 431,107-118.
L. Tao and A.M. English (2004) Protein S-glutathiolation triggered by decomposed S-nitrosoglutathione, Biochemistry 43, 4228-4038.
S.M. Aitken, M. Ouellet, M. D. Percival and A. M. English (2003) Mechanism of horseradish peroxidase inactivation by benzhydrazide: a critical evaluation of arylhydrazides as peroxidase inhibitors, Biochem. J. 375, 613-621.
A.A. Romeo, J.A. Capobianco and A.M. English (2003) Superoxide dismutase targets NO from GSNO to Cysb93 of oxyhemoglobin in concentrated but not dilute solutions of the protein, J. Am. Chem. Soc. 125,14370-14378.
P. J. Wright and A.M. English (2003) Scavenging with TEMPO• to identify peptide-and protein-based radicals by mass spectrometry: Advantages of spin scavenging over spin trapping, J. Am. Chem. Soc. 125, 8655-8665.
R. Papp, I. Ekiel and A.M. English (2003) ESI-MS and FTIR studies of the interaction between the second PDZ domain of hPTP1E and target peptides, Biochem. Cell Biol. 81, 71-80.
L. Tao and A.M. English (2003) Mechanism of S-nitrosation of recombinant human brain calbindin D28K, Biochemistry 42, 3326-3334.
G. Tsaprailis and A.M. English (2003) Mass spectral analysis of tyrosyl radicals generated in yeast cytochrome c peroxidase and its W191F mutant on reaction with H2O2, J. Biol. Inorg. Chem. 8, 248-255.
C. Toubin, D. Y.-H. Yeung, A.M. English and G.H. Peslherbe (2002) Theoretical Investigations of S-nitrosothiol Degradation: Probing the Catalytic Role of Copper Ions, J. Am. Chem. Soc. (Chem. Comm.) 124, 14816-1481.
J. Heng and A. M. English (2002) Quantitative Analysis of the Yeast Proteome by Incorporation of Labeled Leucine, J. Proteome Res. 1, 345-350.
A.A. Romeo, J.A. Capobianco and A.M. English (2002) Reaction of deoxyhemoglobin with S-nitrosogluthatione requires copper, J. Biol. Chem. 277, 24135-24141.
L. Tao, M.E.P. Murphy and A.M. English (2002) S-Nitrosation of Ca-loaded and Ca-free recombinant calbindin D28K from human brain, Biochemistry 41, 6185-6192.
S. Akhter, A. Vignini, Z. Wen, A.M. English, P.G. Wang and B. Mutus (2002) Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation, Proc. Natl. Acad. USA 99, 9172-9177.
S. M. Aitken, J.L. Turnbull, M.D. Percival and A.M. English (2001) Thermodynamic analysis of the binding of aromatic hydroxamic acid analogs to ferric horseradish peroxidase, Biochemistry 40, 13980-13989.
A. Filosa, Y. Wang, A.A. Ismail and A.M. English (2001) Two-dimensional correlation spectroscopy as a probe of the sequential events in the thermal unfolding of cytochromes c, Biochemistry 40, 8256-8263.
D.E. Wilcox and A.M. English (2001) Effects of metal ions on the oxidation and nitration of cysteine residues in proteins and enzymes, Eds. A. Sigel and H. Sigel, Metal Ions in Biological Systems, Vol 38. Marcel Dekker, New York, pp 313-350.
A. Filosa and A.M. English (2001) Mass spectral analysis of protein-based radicals using DBNBS: Non-radical adduct formation vs spin trapping, J. Biol. Chem. 276, 21022-21027.
P.J. Wright and A.M. English (2001) Buffer anions promote leaching of Ca from horseradish peroxidase at low pH: Possible shielding role of carbohydrate, J. Biol. Inorg. Chem. 6, 348-358.
A.A. Romeo, A. Filosa, J.A. Capobianco and A.M. English (2001) Metal chelators inhibit S-nitrosation of Cysb93 in oxyhemoglobin, J. Am. Chem. Soc. (Chem. Comm) 123, 1782-1783.
A. Filosa and A.M. English (2000) Probing local thermal stabilities of bovine, horse and tuna ferricytochromes c at pH 7, J. Biol. Inorg. Chem. 5, 448-454.