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Great Concordian: Michael Meaney, groundbreaking neuroscientist

‘Your ability to recover from setbacks will determine how successful you become’
July 31, 2024
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By Ian Harrison, BComm 01


 Black and white portrait of a man with a beard and medium-length hair, wearing a patterned shirt and a jacket. Michael Meaney, BA 75, MA 77, PhD 82

Michael Meaney, BA 75, MA 77, PhD 82, is a distinguished figure in the field of biological psychiatry and neurodevelopment.

The James McGill Professor of Medicine at McGill University’s Douglas Mental Health University Institute, Meaney is renowned for his groundbreaking research into the effects of early experience on gene expression and development.

His inquiries into the complex interplay between genetics, environment and neurodevelopment span decades, with a primary focus on understanding how variations in maternal care influence outcomes. Through pioneering studies in animal models, he has uncovered the intricate mechanisms by which early experiences shapes gene expression, brain development and responses to stress.

Beyond the lab, Meaney’s body of work holds significant implications for human health and well-being, informing both clinical practice and public policy. With more than 650 journal articles to his name, Meaney’s numerous accolades include induction into the Order of Canada and election to the American Academy of Arts and Sciences.

A proud alumnus of Loyola College, Meaney has fond recollections of the hockey rivalry the school enjoyed with Sir George Williams University before the two institutions merged to become Concordia in 1974.

Concordia is “an insanely interesting hybrid that has grown immensely,” he says.

When you reflect on your time as a Concordia student, what stands out?

Michael Meaney: It was at Loyola and later Concordia where I figured out what I wanted to do with the rest of my life. I took a genetics course where I learned what makes a frog a frog and a salamander a salamander, et cetera. I told the professor, this is great, but I’m more interested in what makes one salamander different from another salamander, what makes one more aggressive and the other less aggressive. The professor told me to take psychology courses, which ended up being pivotal.

And then I was in the library one night back in the 1970’s and discovered that one of the pathways that rendered individuals vulnerable to heart disease was their reactivity to stress. I thought, my goodness, that means that essentially the quality of your early life could give rise to a risk for heart disease. I thought, well, if that’s true, just think of the degree to which biology must be responsive to all of these early life events.

I brought that to [professor emerita] Jane Stewart and she allowed me to capture it in the context of my PhD thesis. And the rest is history.

What are some of the factors that have enabled your success?

MM: My level of personal ambition was pretty high at Concordia, but I’m not sure where I would be without Jane Stewart’s mentorship. She nurtured my interests and set me on the path to my subsequent training, which was at the Rockefeller University in New York — an institute that gives only one degree, a PhD in biological sciences, and has 34 laboratories, with 17 of them headed by Nobel laureates. While there I was fortunate enough to work with Bruce McEwen, who was basically the biological science version of Jane, and just an amazing human being.

What advice do you have for students who may want to follow in your footsteps?

MM: You have to want it. And most of all, it has to be fun. You have to enjoy it and be open to uncertainty and challenges.

You also have to get accustomed to failure, otherwise the winning is no joy. Your ability to recover from setbacks will determine how successful you become.

How does it feel to be a Great Concordian?

MM: It honestly feels fantastic. It makes me reflect on how fortunate I’ve been to have mentored so many graduate students and postdocs, and to draw from my own experiences as a student to enable their success. For me, gratitude has always come from how they’re able to seize opportunities that I can provide. It’s a different perspective being on this end of the recognition, but it’s something I very much appreciate.

Take pride in our Great Concordians!



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